Optimized State of Extraction of Phenolic Compounds of Boscia senegalensis (Pers.) Lam. ex Poir. and Evaluation of their Antihyperglycemic Activities
Published: 29-07-2024
Page: 702-713
Issue: 2024 - Volume 3 [Issue 3]
Thierry Togdjim *
Faculty of Exact and Applied Sciences (FSEA), University of N’Djamena, BP: 1117 N’Djamena, Chad.
Imar Djibrine Soudy
Faculty of Human Health Sciences (FSSH), University of N’Djamena, BP: 1117 N’Djamena, Chad and Food Quality Control Center (CECOQDA), BP: 4486 N’Djamena, Chad.
Mbaiguinam Mbailao
Faculty of Exact and Applied Sciences (FSEA), University of N’Djamena, BP: 1117 N’Djamena, Chad.
Laurent Kodji
Faculty of Exact and Applied Sciences (FSEA), University of N’Djamena, BP: 1117 N’Djamena, Chad.
Aristide Kemoral
Faculty of Exact and Applied Sciences (FSEA), University of N’Djamena, BP: 1117 N’Djamena, Chad.
*Author to whom correspondence should be addressed.
Abstract
Introduction: The resurgence of diabetes and some side effects of synthetic drugs used for its treatment led us to study a plant used in traditional medicine, Boscia senegalensis for its treatment. This work aims to optimize the aqueous extract of B. senegalensis and to evaluate its antihyperglycemic activity.
Methods: For this study, several phytochemical assays were performed, to obtain extracts with better concentrations and good effectiveness.
Results: The analyses allowed to see the possible correlations between the variables (time and mass of the powder) then the answers show that the effects have P values 0.05. This indicates that they are significantly different from zero to 95.0% confidence level with different optimal areas for good extraction of phenolic compounds from this plant. Several experiments are performed on normoglycemic rats on the model of oral-induced hyperglycemia. The extract is administered at a single dose of 200 mg/kg in proportion to the animal’s weight. Blood sugar normally varies up to a level where the extract has its effects. The peaks are reached at 30 min showing here that the extracts significantly lower blood sugar.
Conclusion: The extracts significantly reduced glycemia taking into account optimization conditions.
Keywords: Boscia senegalensis, optimization, extraction, phenolic compounds, antihyperglycemia