An Assessment of Potential In-vivo Hepatoprotective Properties of Vitis vinifera in Experimental Rat Model
Published: 17-06-2023
Page: 255-265
Issue: 2023 - Volume 2 [Issue 4]
Najibah Nasrin
Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh.
Md. Abu Sufian
Molecular Pharmacology and Herbal Drug Research Laboratory, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh.
Maliha Rownak Ara Khan
Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.
Fahmida Maliha
Department of Pharmacy, East West University, Dhaka-1212, Bangladesh.
Marufa Islam
Department of Pharmacy, Daffodil International University, Bangladesh.
Abul Khair Muhammad Foyaz Mia
Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.
Amrin Yeasin Proma
Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.
Fahima Afroja
Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.
Sara Rahmat
Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.
Jasim Uddin
Department of Chemistry, University of Dhaka, Dhaka-100, Bangladesh.
Fahima Aktar
Molecular Pharmacology and Herbal Drug Research Laboratory, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh.
Tahmina Akter
Department of Physiology, Dhaka Medical College, Dhaka, Bangladesh.
K. M. Khairul Alam
Department of Pharmacy, Jahangirnagar University, Savar, Dhaka-1342, Bangladesh.
Jakir Ahmed Chowdhury
Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh.
Shaila Kabir
Molecular Pharmacology and Herbal Drug Research Laboratory, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh.
Abu Asad Chowdhury
Molecular Pharmacology and Herbal Drug Research Laboratory, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh.
Md. Shah Amran
Molecular Pharmacology and Herbal Drug Research Laboratory, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh.
*Author to whom correspondence should be addressed.
Abstract
Many civilizations have long employed herbal treatments to treat ailments. It has been shown that these medicinal plants contain a number of phytochemicals that can treat a variety of ailments, from minor to serious. A focused search for alternative natural therapeutic agents was inspired by the shortcomings of traditional medications and their peculiar adverse effects. The availability of natural products and their lack of negative side effects could be another explanation for this goal.
Human healthcare has historically benefited greatly from the grape plants and the ingestion of grape fruits. Vitis vinifera is known to have astringent, demulcent, carminative, diuretic, laxative, wound-healing, stomachic characteristics. V. Vinifera are widely used to treat bronchitis, allergies, the common cold, the flu, anemia, and other conditions. The blooms are also known to have expectorant and hematinic effects. Moreover, there are broad spectrum anti-inflammatory, anti-hypertensive, antineoplastic, anti-carcinogenic, anti-fibrotic, anti-viral, anti-fungal, anti-bacterial, anti-ulcerant, anti-aging, anti-asthma, anti-obesity, hyperpigmentation, wound-healing (cicatrizing) properties as well as immunomodulatory, cardio-protective, and neuroprotective roles have been reported.
The present study looked into the unexplored hepatoprotective and anti-oxidant potentialities of ethanolic fruit extract of V. vinifera against toxic chemical CCl4-induced hepatotoxicity in male Wistar rats. In the present study, the extract shows a tremendous result as a hepato-protective and an antioxidant agent considering (p*<0.05) in a dose-dependent manner. In lower doses the grape extract shows reversing physiological effects and in higher doses, it shows better therapeutic effects comparing the marketed drugs for hepatoprotective response.
Keywords: Hepato-protective, V. vinifera, CCl4, cardio-protective, Wister rat