An Assessment of Anti-hyperlipidemic Potentialities of Ethanolic Extract of Hemidesmus indicus in High Fat Induced Rat Model
Published: 09-07-2023
Page: 323-330
Issue: 2023 - Volume 2 [Issue 4]
Juliana Aditi Baroi
Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.
Md. Rakib Hossian
Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.
Md. Mustafiz Chowdhury
Department of Pharmacy, University of Chittagong, Bangladesh.
Nur-Neasha Dolon
Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.
Fahmida Maliha
Department of Pharmacy, East West University, Dhaka 1212, Bangladesh.
Md. Abdullah Hil Baky Rupak
Department of Pharmaceutical Sciences, North South University, Plot # 15, Block # B, Bashundhara R/A, Dhaka, 1229, Bangladesh.
Navila Nawjesh Lima
Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.
Md. Rahmat Ullah
Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.
Rafat Tahsin *
Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.
*Author to whom correspondence should be addressed.
Abstract
The art or practice of utilizing herbs and herbal preparations to preserve health and to prevent, treat, or cure illness is referred to as herbal remedies. Rats were utilized to examine the lipid, liver, and renal profiles of hemidesmus indicus extract. Compared to the positive control group, triglycerides dropped in groups 4,5 and 6, but not significantly. At doses of 1000 and 1500 mg/kg, the extract decreased total cholesterol (p<0.05). Only higher doses of 1500mg/kg markedly decreased HDL and LDL levels as compared to the positive control (p<0.05). The doses of 1000 and 1500 mg/kg significantly decreased the SGPT in liver function tests. Serum glutamic-oxaloacetic transaminase (SGOT) concentrations were lowered only by dosages of 1500mg/kg (p<0.05). The levels of creatinine were considerably lowered by all doses of 500, 1000, and 1500mg/kg (p< 0.05). Only doses of 1500mg/kg or above reduced urea in comparison to the positive control group. Groups 7,8, and 9 had the same outcomes as the negative control group but were not statistically significant because they only got the lower, medium, and higher extract dosages. Patients with liver, kidney, and cardiovascular diseases might reap advantages from these discoveries.
Keywords: Herbal remedies, Hemidesmus indicus, cholesterol, cardiovascular patient, phytopharmacology