An Evaluation of Anti-hyperlipidemic Activity of Ethanolic Extract of Cinnamomum tamala leaves in High Fat Induced Rodent Model
Published: 09-07-2023
Page: 331-339
Issue: 2023 - Volume 2 [Issue 4]
Farhana Yesmin Peya
Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.
Sayma Akter Nirzana
Department of Pharmacy, East West University, Dhaka-1212, Bangladesh.
Isratul Jannat Mim
Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.
Tasnimur Rahman Khan
Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.
Souvik Kumar Mandal
Department of Pharmacy, Gono Bishwabidyalay, Mirzanagor, Savar, Dhaka, Bangladesh.
Masruk Alam
Department of Pharmacy, Southeast University, Dhaka, Bangladesh.
Redwanul Haque
Department of Pharmacy, Northern University Bangladesh, Dhanmondi, Dhaka, Bangladesh.
Najmus Sakib Minhaj
Department of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh.
Tasnia Rahman
Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.
Rafat Tahsin *
Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.
*Author to whom correspondence should be addressed.
Abstract
Background: Hyperlipidaemia is a strong predictor of atherosclerosis, coronary artery disease, and cerebrovascular disease. A variety of medicines for the treatment of hyperlipidaemia are still available. Life Societies always need to improve antihyperlipidemic medicines. Because plant products are often thought to be less harmful and devoid of side effects than synthetic ones, investigating plants for novel anti-hyperlipideamic therapies has become an exciting field for life science researchers. Scientific study on Cinnamomum tamala reveals that this plant has a large biological potential as an antihyperlipidemic, and a significant interest in Cinnamomum tamala medicinal characteristics has led to numerous in vitro and in vivo animal investigations.
Methods: Fresh Cinnamomum tamala leaves were gathered Fresh Cinnamomum tamala leaves were gathered and dried via shed drying. Next it was socked in 70% ethanol. The solution was the kept in metabolic shaker for continuous vigorous shaking.After 21 days the solution was filtered and then evaporation was done using rotary evaporator. create ethanolic extracts for testing pharmacological parameters. In rats, hyperlipidaemia was created by giving them a high fat diet (HFD) for ten weeks in a row. Dried leaves extract and Atorvastatin were given 2 hours before rats were fed HFD. The effect of Cinnamomum tamala leaf extract on blood lipid profiles such as TC, TG, HDL, and LDL, as well as biochemical markers such as SGOT and SGPT, was calculated using the Humalyzer 3000.
Results and Discussion: In both high fat diet-induced hyperlipidaemic rats, Cinnamomum tamala leaf extract dramatically lowered TC, TG, LDL, and increased HDL. The treatment of C. tamala leaf extract considerably (P 0.001) lowered the levels of SGOT and SGPT in the experimental groups. In high fat diet-induced hyperlipidaemia, Cinnamomum tamala leaf extract was found to be more effective than Atorvastatin. Cinnamomum tamala leaf extract had a dose-dependent antihyperlipidemic effect in both high fat diet-induced hyperlipidaemic rats after 10 weeks and 2 weeks of therapy. The findings show that the Cinnamomum tamala leaf extract has antihyperlipidemic activity.
Conclusion: This study revealed that Cinnamomum tamala might be used as an antihyperlipidemic herb. In the future, rigorous and systematic research into plant chemistry and pharmacology may reveal a new dimension that will help in the discovery of antihyperlipidemic medications from this plant in cholesterol and creatinine level control to preserve efficient kidney and liver function.
Keywords: Hyperlipidaemia, Cinnamomum tamala, herb, extract, high fat
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